1. Baseline characteristics.
| Study ID |
Randomised participants, N |
Mean age (range) | Mean body weight, kg | Health condition | Reported dose of alcohol |
Duration of intervention |
Baseline SBP (SD) | Baseline DBP (SD) | Baseline HR (SD) |
| Agewall 2000 | 12 | 31 (younger than 40 years old) | Not reported | Healthy, normotensive non‐smokers | 31.25 g | 10 minutes | 121 (6) | 79 (4) | 61 (7) |
| Barden 2013 | 24 | 56 (20 to 65) | Not reported | Healthy | 41 g | 30 minutes | 115 (11) | 72 (6) | 62 (7) |
| Bau 2005 | 100 | 20.7 (18 to 25) | Not reported | Healthy non‐smokers | 60 g | 30 minutes | 114.2 | 64.8 | 72.43 (10.9) |
| Bau 2011 | 70 | 20.7 (18 to 25) | Not reported | Healthy | 60 g | 30 minutes | Not reported | Not reported | 75 (10) |
| Buckman 2015 | 72 | 21.5 | Not reported | Healthy | 0.90 mL/kg for men 0.78 mL/kg for women |
15 minutes | 116.9 (13.5) | Not reported | 66.9 (9.9) |
| Chen 1986 | 20 | 19 to 32 | Not reported | Healthy, normotensive non‐smokers | Target to achieve blood level of 0.05% | Not reported (mentioned that fairly fast rate) |
118 (12.88) | 62.25 (5.1) | 63.13 (7.1) |
| Cheyne 2004 | 17 | 35 (21 to 46) | Not reported | Type 1 diabetes | 0.35 mg/kg BW | Not reported | 116.2 (18.7) | 66.8 (8.2) | 70 (12) |
| Dai 2002 | 40 | 19 to 25 years | 81.35 | Healthy | 0.5 g/kg | 5 minutes | 114.1 | 72.6 | 63.5 |
| Dumont 2010 | 14 | 22.1 (18 to 29) | Not reported | Regular user of MDMA, otherwise healthy | Target blood alcohol level 0.6%, equivalent of 2 to 3 alcoholic beverages. | 3 hours to maintain target BAC | Not reported | Not reported | 66 |
| Fantin 2016 | 18 | 34.2 (25 to 53) | 70.2 (53 to 85.6) | Healthy | 30 g | 10 hours | 110.3 (12) | 80 (8) | 75.5 (11.5) |
| Fazio 2004 | 10 | 22 (20 to 25) | Not reported | Healthy | 0.3 g/kg | 5 minutes | Not reported | Not reported | 68 |
| Foppa 2002 | 13 | 55 (43 to 65) | Not reported | Hypertensive and centrally obese | 23 g | 15 minutes | 130 | 83 | 72 (8.72) |
| Hering 2011 | 24 | 44 | Not reported | 13 hypertensive and 11 normotensive | 1 g/kg | 20 minutes | Hypertensive: 150
(21) Normotensive: 136 (13.2) |
Hypertensive: 91 (14.4) Normotensive: 76 (10) |
Hypertensive: 72 (7.2) Normotensive: 70 (10) |
| Karatzi 2005 | 15 | 52.4 | Not reported | Coronary artery disease | 30 g | Not reported | 109.8 (9.2) | 80.7 (10.8) | 67.1 (13.1) |
| Karatzi 2013 | 16 | 28.5 | 77.5 | Healthy non‐smokers | 20 g | 15 minutes | 115.4 (6.2) | 68.5 (5.4) | 60 (8.1) |
| Kawano 1992 | 13 | 55.2 (22 to 70) | 65.2 | Mild to moderate essential hypertension | 51 g | Not reported | 159 (18.8) | 91.3 (12) | 61.5 |
| Kawano 2000 | 10 | 54 (32 to 67) | 70 (60 to 78) | Mild essential hypertension | 55.3 g (1 mL/kg BW) | 60 minutes | 147 | 91 | 65 |
| Koenig 1997 | 15 | 20 to 35 | 76 | Healthy | 10 mL/kg BW | 30 minutes | 127 (11) | 80 (9.5) | Not reported |
| Kojima 1993 | 21 | 56.5 (33 to 73) | Not reported | Essential hypertension | 1 mL/kg BW | 30 minutes | 146 (18.33) | 89 (9.2) | 59 (9.2) |
| Mahmud 2002 | 8 | 21 to 40 | 70 | Healthy, normotensive non‐smokers | 56 g (0.8 g/kg of BW) | 10 minutes | 93.3 (10) | 67 (8) | Not reported |
| Maufrais 2017 | 24 | 23.3 | 62.9 | Healthy | 0.4 g/kg | 5 minutes | Not reported | Not reported | 69 (9.8) |
| Maule 1993 | 10 | 31 (22 to 51) | 68.1 (50 to 81) | Healthy | 34 g (0.5 g/kg BW) | 10 minutes | 122 | 70 | 62 (6.3) |
| Narkiewicz 2000 | 19 | 26 | Not reported | Healthy | 1 g/kg BW | 30 minutes | 111 (11.2) | 61 (7.5) | 57 (7.5) |
| Nishiwaki 2017 | 11 | 21.1 (20 to 22) | 62.6 | Healthy non‐smokers | 11 g and 19.25 g | 5 minutes | 123 (6.63) | 71 (6.63) | 59 (9.94) |
| Potter 1986 | 16 | 22 (20 to 30) | 77 | Healthy, normotensive | 0.75 g/kg | 15 minutes | 122.5 (11) | 72.5 (9) | 63.2 (8) |
| Rosito 1999 | 40 | 22.2 (19 to 30) | Not reported | Healthy | 60 g | 1 hour | 124.2 (10.7) | 76.2 (9.4) | 70.5 (12.6) |
| Rossinen 1997 | 20 | 39 to 68 | Not reported | Coronary artery disease and
myocardial ischaemia Patients were taking usual medicine |
1.25 g/kg | 1 hour 30 minutes | 132 (16) | Not reported | 69.5 |
| Stott 1987 | 10 | 18 to 31 | 56 to 101 | Healthy | 1.3 g/kg | 1 hour | 115.5 | 67 | 70.5 |
| Stott 1991 | 8 | 81 (70 to 96) | 68.4 | Normotensive | 0.5 g/kg | 15 minutes | 130 (18.3) | 77.5 (15.5) | 57 (7.5) |
| Van De Borne 1997 | 16 | 26 | Not reported | Healthy | 1 g/kg | 30 minutes | Not reported | Not reported | 59 (8) |
| Williams 2004 | 13 | 59 (48 to 70) | 86 | Coronary artery disease | 0.52 g/kg | 20 minutes | 135 (11) | 82 (7) | 55 (11) |
| Zeichner 1985 | 48 | 20.9 (19 to 23) | Not reported | Healthy | 1 g/kg | 20 minutes | 115.5 (10.2) | 70.4 (9.1) | 69.4 (12.10) |
BAC: blood alcohol concentration. BW: body weight. DBP: diastolic blood pressure. HR: heart rate. SBP: systolic blood pressure. SD: standard deviation.