5. Differences between older and younger participants.

Analysis	Older participants (mean age ≥ 50),  mean difference, IV, fixed‐effect model, 95% CI	Younger participants (mean age < 50), mean difference, IV, fixed‐effect model, 95% CI
2.1 SBP (< 6 hours)	‐11.25 [‐15.63, ‐6.87] Test for overall effect: Z = 5.04 (P < 0.00001); df = 3 (P = 0.03); I² = 66%	‐2.52 [‐5.78, 0.74]  Test for overall effect: Z = 1.52 (P = 0.13); df = 5 (P = 0.31); I² = 16%
2.2 DBP (<6 hours)	‐7.82 [‐11.08, ‐4.57]  Test for overall effect: Z = 4.71 (P < 0.00001); df = 3 (P = 0.008); I² = 74%	‐1.66 [‐4.22, 0.89]  Test for overall effect: Z = 1.28 (P = 0.20); df = 5 (P = 0.91); I² = 0%
3.1 SBP (<6 hours)	‐6.71 [‐11.23, ‐2.18] Test for overall effect: Z = 2.91 (P = 0.004); df = 3 (P = 0.92); I² = 0%	‐3.04 [‐4.87, ‐1.20];  Test for overall effect: Z = 3.24 (P = 0.001); df = 11 (P = 0.010); I² = 56%
3.2 DBP (<6 hours)	‐4.30 [‐7.32, ‐1.27]  Test for overall effect: Z = 2.78 (P = 0.005); df = 2 (P = 0.25); I² = 27%	‐1.67 [‐3.33, ‐0.01] Test for overall effect: Z = 1.97 (P = 0.05); df = 10 (P = 0.13); I² = 34%

CI: confidence interval.
DBP: diastolic blood pressure.
IV: inverse variance.
SBP: systolic blood pressure.