6. Comparison between very high‐dose alcohol and lower high‐dose alcohol.

Outcomes	Very high dose (≥ 60 g) Mean difference, IV, fixed‐effect model, 95% CI	Lower high dose (31 to 59 g)  Mean difference, IV, fixed‐effect model, 95% CI
3.1. SBP	‐5.12 [‐7.32, ‐2.92] Test for overall effect: Z = 4.57 (P < 0.00001); df = 7 (P = 0.02); I² = 56%	‐1.20 [‐3.90, 1.49] Test for overall effect: Z = 0.88 (P = 0.38); df = 7 (P = 0.47); I² = 0%
3.2. DBP	‐3.21 [‐5.49, ‐0.92] Test for overall effect: Z = 2.75 (P = 0.006); df = 5 (P = 0.22); I² = 29%	‐1.65 [‐3.53, 0.23] Test for overall effect: Z = 1.72 (P = 0.09); df = 7 (P = 0.10); I² = 41%
3.3. MAP	2.17 [‐4.09, ‐0.25] Test for overall effect: Z = 2.21 (P = 0.03); df = 7 (P = 0.04); I² = 52%	‐0.47 [‐2.83, 1.90] Test for overall effect: Z = 0.39 (P = 0.70); df = 8 (P = 0.63); I² = 0%
3.4. HR	5.43 [3.76, 7.11] Test for overall effect: Z = 6.35 (P < 0.00001); df = 9 (P = 0.76); I² = 0%	6.09 [3.67, 8.51] Test for overall effect: Z = 4.93 (P < 0.00001); df = 6 (P = 0.005); I² = 67%

CI: confidence interval.
DBP: diastolic blood pressure.
HR: heart rate.
IV: inverse variance.
MAP: mean arterial pressure.
SBP: systolic blood pressure.