Comparison 2. Medium‐dose alcohol vs placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
2.1 Systolic blood pressure	9		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
2.1.1 ≤ 6 hours	9	260	Mean Difference (IV, Fixed, 95% CI)	‐5.63 [‐8.25, ‐3.02]
2.1.2 7 to 12 hours	4	108	Mean Difference (IV, Fixed, 95% CI)	‐3.22 [‐8.37, 1.93]
2.1.3 ≥ 13 hours	4	112	Mean Difference (IV, Fixed, 95% CI)	0.64 [‐3.90, 5.18]
2.2 Diastolic blood pressure	9		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
2.2.1 ≤ 6 hours	9	260	Mean Difference (IV, Fixed, 95% CI)	‐4.01 [‐6.02, ‐2.00]
2.2.2 7 to 12 hours	4	108	Mean Difference (IV, Fixed, 95% CI)	‐1.19 [‐4.29, 1.90]
2.2.3 ≥ 13 hours	4	112	Mean Difference (IV, Fixed, 95% CI)	1.78 [‐0.95, 4.51]
2.3 Mean arterial blood pressure	12		Mean Difference (IV, Random, 95% CI)	Subtotals only
2.3.1 ≤ 6 hours	12	360	Mean Difference (IV, Random, 95% CI)	‐2.92 [‐5.76, ‐0.07]
2.3.2 7 to 12 hours	4	108	Mean Difference (IV, Random, 95% CI)	‐2.11 [‐4.69, 0.48]
2.3.3 ≥ 13 hours	4	112	Mean Difference (IV, Random, 95% CI)	1.43 [‐1.18, 4.04]
2.4 Heart rate	12		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
2.4.1 ≤ 6 hours	12	344	Mean Difference (IV, Fixed, 95% CI)	4.62 [3.14, 6.11]
2.4.2 7 to 12 hours	4	108	Mean Difference (IV, Fixed, 95% CI)	1.22 [‐1.88, 4.32]
2.4.3 ≥ 13 hours	3	72	Mean Difference (IV, Fixed, 95% CI)	1.37 [‐2.12, 4.86]