Comparison 3. High‐dose alcohol vs placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
3.1 Systolic blood pressure	16		Mean Difference (IV, Random, 95% CI)	Subtotals only
3.1.1 ≤ 6 hours	16	620	Mean Difference (IV, Random, 95% CI)	‐3.49 [‐6.03, ‐0.95]
3.1.2 7 to 12 hours	3	88	Mean Difference (IV, Random, 95% CI)	‐3.72 [‐6.97, ‐0.48]
3.1.3 ≥ 13 hours	4	188	Mean Difference (IV, Random, 95% CI)	3.69 [2.33, 5.05]
3.2 Diastolic blood pressure	14		Mean Difference (IV, Random, 95% CI)	Subtotals only
3.2.1 ≤ 6 hours	14	532	Mean Difference (IV, Random, 95% CI)	‐1.91 [‐3.86, 0.04]
3.2.2 7 to 12 hours	3	88	Mean Difference (IV, Random, 95% CI)	‐1.71 [‐4.59, 1.17]
3.2.3 ≥ 13 hours	4	188	Mean Difference (IV, Random, 95% CI)	2.37 [0.25, 4.49]
3.3 Mean arterial blood pressure	17		Mean Difference (IV, Random, 95% CI)	Subtotals only
3.3.1 ≤ 6 hours	17	640	Mean Difference (IV, Random, 95% CI)	‐1.53 [‐3.34, 0.28]
3.3.2 7 to 12 hours	3	88	Mean Difference (IV, Random, 95% CI)	‐2.47 [‐5.69, 0.75]
3.3.3 ≥ 13 hours	4	188	Mean Difference (IV, Random, 95% CI)	2.96 [0.35, 5.58]
3.4 Heart rate	17		Mean Difference (IV, Random, 95% CI)	Subtotals only
3.4.1 ≤ 6 hours	17	704	Mean Difference (IV, Random, 95% CI)	5.75 [3.99, 7.51]
3.4.2 7 to 12 hours	5	198	Mean Difference (IV, Random, 95% CI)	6.16 [3.04, 9.28]
3.4.3 ≥ 13 hours	6	298	Mean Difference (IV, Random, 95% CI)	2.70 [0.80, 4.60]