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. 2021 Mar 17;2021(3):CD004406. doi: 10.1002/14651858.CD004406.pub5

Comparison 3. Azithromycin versus amoxicillin.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
3.1 Clinical cure at 24 to 28 days (ITT) 1 673 Odds Ratio (M‐H, Fixed, 95% CI) 0.76 [0.55, 1.05]
3.1.1 Children 1 673 Odds Ratio (M‐H, Fixed, 95% CI) 0.76 [0.55, 1.05]
3.2 Clinical cure at 24 to 28 days (bacteriological per protocol population) 1 482 Odds Ratio (M‐H, Fixed, 95% CI) 0.29 [0.11, 0.73]
3.2.1 Children 1 482 Odds Ratio (M‐H, Fixed, 95% CI) 0.29 [0.11, 0.73]
3.3 Relapse on day 38 to 45 (ITT) 1 673 Odds Ratio (M‐H, Fixed, 95% CI) 0.75 [0.55, 1.02]
3.3.1 Children 1 673 Odds Ratio (M‐H, Fixed, 95% CI) 0.75 [0.55, 1.02]
3.4 Relapse on day 38 to 45 (bacteriological per protocol) 1 422 Odds Ratio (M‐H, Fixed, 95% CI) 0.88 [0.43, 1.82]
3.4.1 Children 1 422 Odds Ratio (M‐H, Fixed, 95% CI) 0.88 [0.43, 1.82]
3.5 Adverse events (all participants) 1 673 Odds Ratio (M‐H, Fixed, 95% CI) 2.67 [1.78, 3.99]
3.5.1 Children 1 673 Odds Ratio (M‐H, Fixed, 95% CI) 2.67 [1.78, 3.99]