AR-FL and AR-V functional domains. NTD, N-terminal domain containing the activation function 1 (AF1); DBD, DNA binding domain; LBD, ligand binding domain containing the activation function 2 (AF2); PIP-box (QLGLGRVY), PCNA-interaction protein box is located at the N-terminus of AR; NLS, nuclear localization signal; TAU-5, transcription activation unit 5.