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PCNA-I1S (P-I1S) inhibits the expression of AR target genes. Western blot analysis was performed using extracts from control (Ctr) cells and cells treated with (A) 1 µM PCNA-I1S for 24 h, (B) 1 µM PCNA-1S for 24 or 48 h, or (C) T2AA for 24 h. (D) RNA samples from cells treated for 24 h with 0.5 µM PCNA-I1S were analyzed for the mRNA levels of AR and PSA by RT-qPCR. *P<0.05, PCNA-I1S vs. control. PCNA, proliferating cell nuclear antigen; PSA, prostate-specific antigen.
