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. Author manuscript; available in PMC: 2021 May 18.
Published in final edited form as: Amyotroph Lateral Scler. 2010 Nov 12;12(2):87–96. doi: 10.3109/17482968.2010.522586

Figure 4. Proteasome inhibition is selectively toxic to PC12 cells expressing mutant G93A SOD1.

Figure 4.

A. Treatment with 100 nM MG132 for 24 h shows no toxicity against any of the cell lines, although large numbers of aggregates are seen in the G85R SOD1 and G93A SOD1 cell lines. B. Treatment with 100 nM MG132 is selectively toxic to the G93A SOD1 cell line after 48 h. C. Washing of the cells at 24 h to remove compound does not reverse toxicity to the G93A SOD1 cell line suggesting that an irreversible toxic event, potentially related to the aggregation of G93A SOD1, has been triggered prior to wash out.