Table 3. Major molecular findings of the aggravation of the disease by endogenous factors and clinical effects.

Pathomechanism	Major findings Cutaneous rosacea	Clinical features
Endogenous factors   - Genetic predisposition	• rs763035 polymorphism located between the HLA-DRA gene involved in immune system • Null mutation polymorphism in the gene which codes for Glutathione S-transferase involved in oxidative stress • rs3733631 polymorphism in the tachykinin 3 receptor gene involved in the neurovascular system • rs11168271, rs731336 and rs11568820 polymorphisms in the vitamin D receptor • Heterozygous and homozygous + 405C / G in the gene that codes for VEGF	Cutaneous rosacea: • Activation or aggravation of inflammation
- Corticosteroids	• Cause a rosacea-like dermatitis induced by steroids • ↑ Expression levels of CYP11A1, CYP21A2, 11β-HSD2 and glucocorticoid receptor in skin rosacea • Glucocorticoids can enhance expression of TLR-2 and increased NF-kB signaling