Fig. 2.

Biomarker of Exposure (BoEs) changes between baseline and Days 6 to 7. Data are mean values expressed as the percentage change from the baseline value. All data, except for eCO, were calculated using biomarker levels from 24-h urine collections at baseline and on Days 6 to 7. eCO levels were calculated from data captured at baseline and on Day 6 to 7. eCO - exhaled carbon monoxide; TNeq - total nicotine equivalents (nicotine, cotinine, 3-hydroxycotinine and their glucuronide conjugates); 1-OHP - 1-hydroxypyrene; 2-AN - 2-aminonaphthalene; 3-HPMA - 3-hydroxypropylmercapturic acid; 4-ABP - 4-aminobiphenyl; CEMA - 2-cyanoethylmercapturic acid; HEMA - 2-hydroxyethylmercapturic acid; S-PMA - S-phenylmercapturic acid; HMPMA - 3-hydroxy-1-methylpropylmercapturic acid; MHBMA - monohydroxybutenyl-mercapturic acid; NNAL - 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol; NNN - N-nitrosonornicotine; o-tol - o-toluidine; AAMA - N-acetyl-S-(2-carbamoylethyl)cysteine; GAMA - N-acetyl-S-(2-hydroxy-2-carbamoylethyl)cysteine.