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Cancer cell plasticity and cancer evolution
(A) Schematic representation of the space of cell plasticity trajectories: a cancer cell (colored sphere) moves along two major axes: differentiation status (Y axis) and lineage commitment (X axis).
(B) Cell plasticity features. Change of cell state for a cancer cell is color coded (initial state: blue, new state: red).
(C) Challenges to address in the study of cell plasticity.
