Table 3.
Gene ontology and KEGG pathway analysis of differentially expressed genes.
| A. Gene ontology analysis | |||
|---|---|---|---|
| Category | GO ID ~ function | Gene count (%) | p-value |
| GOTERM_BP | GO:0030198 ~ extracellular matrix organization | 7 (36.8) | 3.87E − 08 |
| GOTERM_BP | GO:0007155 ~ cell adhesion | 8 (42.1) | 2.67E − 07 |
| GOTERM_BP | GO:0035987 ~ endodermal cell differentiation | 3 (15.8) | 3.75E − 04 |
| GOTERM_BP | GO:0022617 ~ extracellular matrix disassembly | 3 (15.8) | 0.002951142 |
| GOTERM_BP | GO:0001501 ~ skeletal system development | 3 (15.8) | 0.009281157 |
| GOTERM_CC | GO:0031012 ~ extracellular matrix | 6 (31.6) | 1.16E − 05 |
| GOTERM_CC | GO:0005615 ~ extracellular space | 9 (47.4) | 0.00207988 |
| GOTERM_CC | GO:0070062 ~ extracellular exosome | 9 (47.4) | 0.00207988 |
| GOTERM_MF | GO:0008201 ~ heparin binding | 4 (21.1) | 5.15E − 04 |
| GOTERM_MF | GO:0005518 ~ collagen binding | 3 (15.8) | 0.001632513 |
| B. KEGG pathway analysis | |||
|---|---|---|---|
| Pathway ID | Pathway | Gene count (%) | p-value |
| hsa04512 | ECM–receptor interaction | 5 (26.3) | 8.1175E − 07 |
| hsa04510 | Focal adhesion | 5 (26.3) | 2.5476E − 05 |
| hsa05222 | Small cell lung cancer | 4 (21.1) | 6.1498E − 5 |
| hsa04151 | PI3K-Akt signaling pathway | 4 (21.1) | 0.00019292 |
| hsa05146 | Amoebiasis | 3 (15.8) | 0.00469651 |
| hsa05200 | Pathways in cancer | 4 (21.1) | 0.00544945 |
ECM extracellular matrix, PI3K-Akt phosphatidylinositol 3-kinase/protein kinase B.