Figure 2.

CaSR phylogenetic tree of mammalian species (a) and alignment of the residues from all four Ca²⁺ binding sites compared between cCaSR and hCaSR (b). (a) Labels are coloured by diet type (green = herbivore; blue = omnivore; pink = carnivore). *—Homo sapiens, **—Felis catus. (b) Sequence alignment comparing the residues that bind Ca²⁺ (blue), GSH (red) or both (purple) for hCaSR and cCaSR. The sites indicated, correspond to Ca²⁺ binding sites on the receptor ²⁰.