Table 3.

Diagnostic test characteristic of MRE, FIB-4, and MRE+FIB-4 (MEFIB Index) in detecting ≥ stage 2 fibrosis in UCSD-NAFLD Cohort and Japan-NAFLD Cohort

	UCSD-NAFLD Cohort					Japan-NAFLD Cohort
Model:	AUROC (95% CI)	OR (95% CI)	p- value*	PPV‡	NPV	AUROC (95% CI)	OR (95% CI)	p- value	PPV‡	NPV
MRE ≥ 3.3kPa †	0.87 (0.81-0.92)	MRE: 71.55 (28.73-178.18)	ref	86.9	91.5	0.79 (0.74-0.85)	MRE: 14.74 (7.60-28.57)	ref	84.6	72.8
FIB-4 ≥ 1.6 †	0.72 (0.66-0.78)	FIB-4: 8.23 (4.32-15.65)	0.0002	61.5	83.7	0.73 (0.68-0.79)	FIB4: 8.31 (4.35-15.88)	0.0792	84.6	60.2
MRE ≥ 3.3kPa + FIB-4 ≥ 1.6	0.90 (0.85-0.95)	MRE: 56.41(21.80-145.94) FIB-4: 5.16 (2.04-13.06)	0.0184	97.1	83.2	0.84 (0.78-0.89)	MRE: 8.96 (4.41-18.22) FIB4: 3.57 (1.69-7.51)	0.0026	91.0	59.4

Abbreviations: PPV, positive predictive value; NPV, negative predictive value; MRE, magnetic resonance elastography, FIB-4, fibrosis – 4

^*p-value for comparison to MRE alone

^†cut-point was derived from the Youden’s Index in the UCSD-NAFLD Cohort

^‡determined by categorizing a positive response as MRE ≥ 3.3kPa and FIB-4 ≥ 1.6 vs any other combination