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. 2021 May 5;12:635076. doi: 10.3389/fimmu.2021.635076

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Copyright © 2021 Zhang, Zhang, Yu, Chen, Zhang, Wei, Zhang, Chen, Lin and Wu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hyperforin downregulated the mRNA expression of AMPs in in skin of IMQ-induced mouse model and TNF-α stimulated HaCaT cells. The mRNA expression of AMPs in the skin lesion of mice model, CRAMP (A), S100A7 (B), S100A8 (C), and S100A9 (D). After pre-treatment with hyperforin, HaCaT cells were stimulated with TNF-α, and RT-qPCR was used to detect the effects of hyperforin on the mRNA expression of LL37 (E), S100A7 (F), S100A8 (G), and S100A9 (H). Data are expressed as fold induction of relevant mRNA sequences compared to untreated controls. Data represent mean ± SEM from at least three independent experiments performed in triplicates; **P < 0.01 vs model group.