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Changes in cytokines in nasal lavage after initiation of ivacaftor therapy (day 0) in two representative CF patients with a G551D mutation. (A) female, age: 27 years, follow up: 5.7 months. (B) male, age: 32 years, follow up: 5.8 months, values shown are relative changes to median of 5 [both (A, B)] measurements prior to ivacaftor. NE, neutrophil elastase; IL, interleukin.
