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. 2021 May 5;12:642180. doi: 10.3389/fimmu.2021.642180

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Copyright © 2021 Mainz, Arnold, Wittstock, Hipler, Lehmann, Zagoya, Duckstein, Ellemunter and Hentschel

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Percentage changes of patients’ inflammation markers levels (dots) and their overall time trends as obtained from linear mixed-effects models. (A) An overall decreasing trend for IL-1β is observed (solid line) over the whole 12-week time period (slope: -0.19 ± 0.09 pg/mL week, p = 0.042 and intercept 2.95 ± 0.49 pg/mL, p < 0.001). (B) An overall decreasing trend (solid line) was observed for IL-8 (slope: -11.48 ± 5.86 pg/mL week, p = 0.049 and intercept 189.76 ± 32.20 pg/mL, p < 0.001). Notice that for clarity, 16 data points surpassing the 100% level in (A) and 5 data points surpassing the 200% level in (B) are not shown.