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. 2021 May 18;12:2899. doi: 10.1038/s41467-021-22833-6

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Fig. 1 — a Mtb ribosomal operon. b The RS ratio (black) mirrored specific growth rate (red) in an in vitro progressive oxygen depletion model. Dots represent values from three independent experiments. Lines connect median values. c In the BALB/c chronic infection model, the lung Mtb CFU burden (blue) rose rapidly and then plateaued over time. The RS ratio (black) indicated rapid initial rRNA synthesis that slowed as Mtb burden plateaued. Dots represent values from three individual mice. Lines connect mean values from each timepoint. Source data are provided as a Source Data file.