Fig. 6. Sputum RS ratio declines rapidly with standard treatment and a dose-response relationship is evident.

a Longitudinal change in the RS ratio in serial sputa among Ugandan and Vietnamese adults treated with HRZE for drug-susceptible TB. Brown and orange dots indicate individual patients from Uganda and Vietnam, respectively. The solid line is a Lowess fit. b Association between rifampin exposure (AUC) and change in sputum RS ratio between pre-treatment and day 14 among Beninese patients treated with HRZE with rifampin 10 mg kg⁻¹ (gray) or 15 mg kg⁻¹ (black).