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. 2021 May 18;7:54. doi: 10.1038/s41523-021-00262-4

Fig. 1. Odds ratios and 95% confidence intervals (CI) per 1 SD increase for metabolites significantly associated with risk of overall breast cancer (p-value < 0.05 and q-value < 0.2) in Nurses’ Health Study II, among premenopausal women only, by BMI category (<25, ≥25)***, and by ER status (ER positive, ER negative)****.

Fig. 1

Creatine, although not selected by the conditional logistic regression (p-value < 0.05, q-value > 0.2), is shown here for completeness, as is was selected by the multivariable models. *Simple model: adjusts for matching factors including menopause status at blood draw, time of blood draw, date/season of blood draw, luteal day at blood draw, fasting status at blood draw, menopausal status at diagnosis and race. **Adjusted model: in addition to matching factors, this model adjusts for BMI at age 18, weight change between age 18 and time of blood draw, age at menarche, parity and age at first birth, family history of breast cancer, personal history of benign breast disease, physical activity, alcohol consumption, exogenous hormone use, and breast feeding history. ***All p-interaction with BMI category were >0.07 except for DMGV p-interaction = 0.04 (simple and adjusted model). ****All p-heterogeneity by ER status were >0.13 except for asparagine p-heterogeneity = 0.02/0.03 (simple/adjusted model).