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. 2021 May 18;11:10469. doi: 10.1038/s41598-021-90010-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Ingenuity Pathway Analysis (IPA) identifying altered canonical pathways, and supportive Western blot analyses (a) Canonical pathways comparisons of FLIGHT vs GC (top) and FLIGHT vs VIV (bottom) indicate involvement of catabolic response and increased oxidative stress via p70S6K, mitochondrial dysfunction, mTOR signaling and NRF2-mediated oxidative stress; color coding indicates directional change in pathway activity (n = 10/group). (b) p70S6 Kinase was reduced vs controls post-FLIGHT (n = 3/group); pAKT (s473) was marginally lower post flight (n = 3/group); Cleaved Caspase-3 was increased post-flight (n = 3/group). *p < 0.05, **p < 0.01.