Table 1.
Shared proteins in the menisci of ground control and vivarium control vs flight mice that are clustered within differential canonical pathways between both controls and flight determined via ingenuity pathway analysis.
| EIF2 | Mitochondrial dysfunction | NRF2 | P70S6K | mTOR |
|---|---|---|---|---|
| EIF2S2 | VDAC1 | GSTP1 | RPS5 | Cdc42 |
| EIF2S3 | ATP6F1A | RAP1A | RAP1A | EIF3B |
| EIF3B | ATP5PD | RAP1B | PPP2R1B | EIF3E |
| EIF3E | GPX4 | EPHX1 | RAP1B | EIF3G |
| EIF3G | ATP5MX | VCP | EIF2S3 | EIF4A1 |
| EIF4A1 | NDUFV1 | MGST3 | RPS21 | EIF4A2 |
| EIF4A2 | ATP5F1C | MAP2K1 | MAP2KA | FKBP1A |
| HRAS | OGDH | GSTM3 | RPS16 | HRAS |
| HSPA5 | SDHA | PRDX1 | RPS4Y1 | PPP2R1A |
| MAP2K1 | FIS1 | GSTM5 | PPP2R1A | PPP2R1B |
| PABPC1 | CYB5A | SOD3 | RPS9 | PPP2R2A |
| PPP1CA | HSD17B10 | MGST1 | RPS20 | RAP1A |
| PPP1CB | UQCRC2 | DNAJB11 | RPS3 | RAP1B |
| RPL13A | PARK7 | GSTK1 | EIF4A1 | RHOA |
| RPL18A | ACO1 | DNAJA2 | RPS24 | RHOC |
| RPL22 | NDUFA9 | RRAS | EIF2S2 | RHOG |
| RPL24 | ATP5PB | CCT7 | RRAS | RPS2 |
| RPL4 | AIFM1 | DNAJA1 | PPP2R2A | RPS3 |
| RPL5 | NDUFA11 | HRAS | HRAS | RPS5 |
| RPL6 | ACO2 | QO2 | EIF3E | RPS9 |
| RPL7 | NDUFA8 | PPIB | PABPC1 | RPS16 |
| RPL7A | DNAJB4 | EIF4A2 | RPS20 | |
| RPL9 | RPS2 | RPS21 | ||
| RPS16 | EIF3G | RPS24 | ||
| RPS2 | RPS4Y1 | |||
| RPS20 | RRAS | |||
| RPS24 | ||||
| RPS3 | ||||
| RPS4Y1 | ||||
| RPS9 | ||||
| RRAS |
Listed proteins are significantly different in both GC and VIV vs FLIGHT with a fold change of 1.5 or greater (p < 0.05).