Table 1.
Physico-chemical parameters and antimicrobial activities of compounds 1 to 1910.
| Compounds | CLogPa | ACD/LogPb | LogD7.40b | MIC (μM)c | |
|---|---|---|---|---|---|
| S. aureus | B. subtilis | ||||
| 1 | 4.67 | 5.55 | 5.38 | L | L |
| 2 | 4.08 | 5.09 | 4.92 | 11.3 | 11.3 |
| 3 | 6.31 | 7.02 | 6.80 | 11.8 | 5.9 |
| 4 | 4.35 | 5.29 | 5.09 | 14.7 | 14.7 |
| 5 | 4.52 | 5.52 | 5.35 | – | – |
| 6 | 6.36 | 7.02 | 6.81 | 23.7 | 23.7 |
| 7 | 3.53 | 4.18 | 4.09 | 25.9 | 25.9 |
| 8 | 3.58 | 4.18 | 3.98 | 25.9 | 25.9 |
| 9 | 4.50 | 5.74 | 5.50 | 22.7 | 22.7 |
| 10 | 5.58 | 6.52 | 6.33 | 5.9 | 5.9 |
| 11 | 5.64 | 6.30 | 6.08 | 5.7 | 5.7 |
| 12 | 6.46 | 7.05 | 6.83 | 5.5 | 5.5 |
| 13 | 6.40 | 7.27 | 7.09 | 5.7 | 5.7 |
| 14 | 3.86 | 4.80 | 4.63 | L | L |
| 15 | 3.92 | 4.58 | 4.37 | L | L |
| 16 | 6.25 | 7.24 | 7.06 | 12.2 | 6.1 |
| 17 | 3.68 | 4.56 | 4.37 | 14.0 | 7.0 |
| 18 | 4.57 | 5.53 | 5.26 | – | – |
| 19 | 2.84 | 3.81 | 3.56 | – | – |
aThe CLogP values were calculated using software ChemBioDraw Ultra 12.0.
bThe ACD/Log P and LogD7.40 values were calculated using software ACD/Labs 6.0.
cMIC, minimum inhibitory concentration; S. aureus, Staphylococcus aureus; B. subtilis, Bacillus subtilis; L, lower activity than other compounds while no data was given; –, no data was given.