Table 2.

Physico-chemical parameters and antimicrobial activities of compounds 20 to 27¹¹.

Compounds	CLogPa	ACD/LogPb	LogD7.40b	MIC (μM)c
				S. aureus	S. epidermidis
20	4.22	5.56	5.34	35.2	70.4
21	5.68	6.54	6.32	4.4	8.8
22	6.01	6.61	6.39	8.5	8.5
23	4.22	5.18	4.96	140.8d	140.8d
24	5.15	6.25	5.97	4.4	4.4
25	6.23	7.02	6.81	18.2	9.1
26	6.38	7.32	7.12	19.6	9.8
27	5.78	6.72	6.51	9.4	9.4

^aThe CLogP values were calculated using software ChemBioDraw Ultra 12.0.

^bThe ACD/Log P and LogD_7.40 values were calculated using software ACD/Labs 6.0.

^cMIC, minimum inhibitory concentration; S. aureus, Staphylococcus aureus ATCC 25923; S. epidermidis, Staphylococcus epidermidis ATCC 12228.

^dBoth MICs of compound 23 against S. aureus ATCC 25923 and S. epidermidis ATCC 12228 were more than 32 μg/mL (70.4 μM). As microdilution broth method was used to test MIC, we set 64 μg/mL (140.8 μM) as their MICs.