Table 3.

Physico-chemical parameters and antimicrobial activities of compounds 21 to 24, and 26 to 33¹².

Compounds	CLogPa	ACD/LogPb	LogD7.40b	MIC (μM)c
				MRSA 6975	MRSA 630	MRSA 6205
28	1.83	3.27	3.04	140.2	280.4d	280.4d
29	3.68	4.60	4.38	36.2	144.6	72.3
30	3.28	4.27	4.05	19.4	155.2	77.6
31	3.91	4.67	4.46	32.9	263.2	263.2
32	4.47	6.10	5.76	18.9	151.5	151.5
33	4.47	5.63	5.29	37.9	151.5	151.5
23	4.22	5.18	4.96	17.6	35.2	35.2
27	5.78	6.72	6.51	18.8	37.7	37.7
21	5.68	6.54	6.32	17.6	8.8	8.8
22	6.01	6.61	6.39	17.1	17.1	8.5
26	6.38	7.32	7.12	4.9	9.8	4.9
24	5.15	6.25	5.97	8.8	8.8	17.6

^aThe CLogP values were calculated using software ChemBioDraw Ultra 12.0.

^bThe ACD/Log P and LogD_7.40 values were calculated using software ACD/Labs 6.0.

^cMIC, minimum inhibitory concentration; MRSA 6975, methicillin-resistant Staphylococcus aureus 6975; MRSA 630, methicillin-resistant Staphylococcus aureus 630; MRSA 6205, methicillin-resistant Staphylococcus aureus 6205.

^dThe MICs of compound 28 against MRSA 630 and 6205 were more than 64 μg/mL (140.2 μM). As microdilution broth method was used to test MIC and the three physico-chemical parameters were small, we set 128 μg/mL (280.4 μM) as their MICs.