Table 5.
Physico-chemical parameters and antimicrobial activities of compounds 17, and 45 to 5414.
| Compounds | CLogPa | ACD/LogPb | LogD7.40b | MIC90 (μM)c | |
|---|---|---|---|---|---|
| MRSA (22) | MSSA (7) | ||||
| 45 | 2.55 | 3.79 | 3.67 | 167.8 | 335.7 |
| 46 | 2.60 | 3.79 | 3.53 | 167.8 | 167.8 |
| 47 | 2.65 | 3.92 | 3.59 | 42.1 | 42.1 |
| 48 | 3.42 | 4.67 | 4.35 | 81.4 | 40.6 |
| 49 | 2.65 | 4.11 | 3.67 | 84.5 | 84.5 |
| 17 | 3.68 | 4.56 | 4.37 | 175.4 | 350.8 |
| 50 | 4.40 | 5.29 | 5.10 | 183.6 | 183.6 |
| 51 | 2.44 | 3.19 | 2.96 | > 918.3 | > 918.3 |
| 52 | 3.32 | 4.51 | 4.27 | 87.8 | 87.8 |
| 53 | 1.37 | 2.42 | 2.11 | 1734.6d | 1734.6d |
| 54 | 3.37 | 4.64 | 4.34 | 88.3 | 88.3 |
aThe CLogP values were calculated using software ChemBioDraw Ultra 12.0.
bThe ACD/Log P and LogD7.40 values were calculated using software ACD/Labs 6.0.
cMIC90, minimum inhibitory concentration to 90% test isolates; MRSA (22), twenty-two isolates of methicillin-resistant Staphylococcus aureus; MSSA (7), seven isolates of methicillin-susceptible Staphylococcus aureus.
dBoth MIC90s of compound 53 against MRSA and MSSA were more than 250 μg/mL (867.3 μM). As microdilution broth method was used to test MIC, we set 500 μg/mL (1734.6 μM) as their MIC90s.