Table 6.

Physico-chemical parameters and antimicrobial activities of compounds 55 to 66¹⁵.

Compounds	CLogPa	ACD/LogPb	LogD7.40b	MIC (μM)c
				MRSA G31	MRSA G47
55	5.58	6.52	6.33	14.7	7.4
56	7.58	8.76	8.70	12.0	6.0
57	3.78	4.72	4.51	16.2	32.3
58	5.53	6.52	6.33	14.7	14.7
59	4.94	5.89	5.67	28.4	7.1
60	4.99	5.89	5.68	28.4	14.2
61	5.71	6.60	6.35	29.4	14.7
62	4.86	5.81	5.62	28.4	28.4
63	4.81	5.81	5.62	28.4	28.4
64	3.68	4.56	4.37	35.1	35.1
65	6.25	7.24	7.06	122.4d	122.4d
66	2.44	3.19	2.96	1469.2	734.6

^aThe CLogP values were calculated using software ChemBioDraw Ultra 12.0.

^bThe ACD/Log P and LogD_7.40 values were calculated using software ACD/Labs 6.0.

^cMIC, minimum inhibitory concentration; MRSA G31 and G47, methicillin-resistant Staphylococcus aureus G31 and G47.

^dBoth MICs of compound 65 against MRSA G31 and G47 were more than 25 μg/mL (61.2 μM). As microdilution broth method was used to test MIC, we set 50 μg/mL (122.4 μM) as their MICs.