TABLE 1.
Inhibitors of Smad signaling pathway.
| Compounds | Pathway | Targets | References(s) |
|---|---|---|---|
| A-77–01 | TGF-β - Smad pathway | TGF-βRI | Wang et al. (2020a) |
| A-83–01 | TGF-β - Smad pathway | TGF-βRI | Wang et al. (2020a) |
| BT173 | TGF-β - Smad pathway | TGF-βRI | Liu et al. (2017) |
| Dorsomorphin | BMP-SMAD pathway | BMPRI | Sakata and Chen (2011) |
| EW-7197 | TGF-β - Smad pathway | TGF-βRI | Wang et al. (2020a) |
| FKBP12 | BMP-SMAD pathway | ALK2 | Sakata and Chen (2011) |
| TGF-β - Smad pathway | TGF-βRI | ||
| GW788388 | TGF-β - Smad pathway | TGF-βRI | Wang et al. (2020a) |
| Heparins | BMP-SMAD pathway | Unknow | Silvestri et al., (2019) |
| IN-1130 | TGF-β - Smad pathway | TGF-βRI | Wang et al. (2020a) |
| Isorhamnetin | TGF-β - Smad pathway | Unknow | Yang et al. (2016b) |
| K02288 | BMP-SMAD pathway | ALK2 | Ali and Brazil (2014) |
| LDN193189 | BMP-SMAD pathway | BMPRI | Silvestri et al. (2019) |
| LY2109761 | TGF-β - Smad pathway | TGF-βRI | Wang et al. (2020a) |
| LY2157299 | TGF-β - Smad pathway | TGF-βRI | Wang et al., (2020a) |
| LY3200882 | TGF-β - Smad pathway | TGF-βRI | Wang et al. (2020a) |
| LY364947 | TGF-β - Smad pathway | TGF-βRI | Wang et al. (2020a) |
| Momelotinib | BMP-SMAD pathway | ALK2 | Silvestri et al. (2019) |
| PFD/FD | TGF-β - Smad pathway | unknow | Wang et al. (2020a) |
| Progesterone | TGF-β - Smad pathway | TGF-βRI | Kunzmann et al. (2018) |
| R-268712 | TGF-β - Smad pathway | TGF-βRI | Wang et al. (2020a) |
| RepSox | TGF-β - Smad pathway | TGF-βRI | Wang et al. (2020a) |
| SB431542 | TGF-β - Smad pathway | TGF-βRI | Wang et al. (2020a) |
| SB-505124 | TGF-β - Smad pathway | TGF-βRI | Wang et al. (2020a) |
| SB-525334 | TGF-β - Smad pathway | TGF-βRI | Wang et al. (2020a) |
| SD-208 | TGF-β - Smad pathway | TGF-βRI | Wang et al. (2020a) |
| SIS3 | TGF-β - Smad pathway | TGF-βRI | Li et al. (2010) |
| Testosterone | TGF-β - Smad pathway | TGF-βRI | Sakata and Chen (2011) |
| TMPRSS6 | BMP-SMAD pathway | ALK2, ALK3 | Silvestri et al. (2019) |
| TP-0427736 | TGF-β - Smad pathway | TGF-βRI | Wang et al. (2020a) |
| Valproic acid | TGF-β - Smad pathway | TGF-βRI | Qi et al. (2019) |
FKBP12: FK506-binding protein 12; PFD: Pirfenidone; FD: fluorofenidone; TMPRSS6: transmembrane serine protease 6; TGF-βRI: TGF-β receptors type I; BMPRI: BMP type I receptor.