Table 1.
Experimental groups.
| Experiment | Drugs | Dosing | Intervention |
|---|---|---|---|
| 1 | Meropenem | 2000 mg over 30 min |
Sham (3 pigs) CytoSorb (3pigs) |
| Linezolid | 600 mg over 30 min | ||
| Fluconazole | 800 mg over 40 min | ||
| Clindamycin | 1200 mg over 40 min | ||
| 2 | Piperacillin | 6000/750 mg over 30 min |
Sham (3 pigs) CytoSorb (3 pigs) |
| Anidulafungin | 200 mg over 60 min | ||
| Ganciclovir | 400 mg over 60 min | ||
| 3 | Ceftriaxone | 4000 mg over 30 min |
CytoSorb (3 pigs) Sham (3 pigs) |
| Clarithromycin | 500 mg over 60 min | ||
| Posaconazole | 300 mg over 30 min | ||
| Teicoplanin | 800 mg over 30 min | ||
| Tobramycin | 320 mg over 30 min | ||
| 4 | Ciprofloxacin | 400 mg over 60 min |
Sham (3 pigs) CytoSorb (3pigs) |
| Cefepime | 2000 mg over 30 min | ||
| Metronidazole | 2000 mg over 30 min | ||
| Amphotericin B (liposomal) | 150 mg over 30 min | ||
| Flucloxacillin | 4000 mg over 30 min |
Pigs received different combinations of drugs, followed by initiation of an extra-corporeal circulation with (cases) or without (sham, control) a CytoSorb cartridge. Three animals were randomly allocated to each group. All drugs were administered intravenously one hour before extra-corporeal circulation initiation.