Table 1.
Table describes the main functions of the different human cytosolic GST isoenzymes. These functions include detoxification, enzymatic functions, and protein S-glutathionylation. Moreover, the table describes the known interacting/target proteins per GST and the main resultant function/effect on the signaling pathway (below the dashed line). The arrows indicate the subsequent effect and/or outcome. 4-HNE: 4-hydroxy-2-nonenal; PSSG: Protein S-glutathionylation; ASK1: apoptosis signal-regulating kinase 1; JNK: c-Jun N-terminal kinase; ERK: Extracellular signal-regulated kinases; Akt: Protein Kinase B; ATP: Adenosine Triphosphate; IL-1β: Interleukin-1beta; TRAF2: tumor necrosis factor receptor associated factor 2.