Table 2.
mRNA and protein expression differences between COPD or asthma vs control.
| GST | Asthma vs control mRNA | Asthma vs control protein | COPD vs control mRNA | COPD vs control protein |
|---|---|---|---|---|
| GSTA | Increased in lung lysates of mild -moderate COPD patients compared to very severe disease and controls; GSTA higher in induced sputum [147]; GSTA + central airway epithelial cells decreased in GOLD stage IV patients. | |||
| GSTA1 | Increased in sputum [199] | Decreased in BALF [223] | ||
| GSTA2 | Decreased in BALF [223] | |||
| GSTM1 | Not different in sputum [199] | Lower in lung tissue [225]; Increased in microarray from bronchial brushing [226]; | ||
| GSTM3 | Increased in microarray from bronchial brushing [226] | |||
| GSTO1 | Decreased in lung tissue and sputum compared to smokers and never smoker controls [147] | |||
| GSTP1 | Downregulation in nasal epithelial cells in children [208], no difference in induced sputum samples [199] | Decreased in peripheral lung [225] | Increased in whole lung homogenates in patients with mild disease, number of GSTP + cells did not differ [147]; lower in BALF [223] | |
| GSTT1 | Not different [199] |
Table describes the differences in mRNA and protein expression of the different GST isoenzymes between COPD patients and controls or asthmatic patients and control subjects. COPD: Chronic Obstructive Pulmonary Disease; GST: Glutathione S-transferase; BALF: Broncho alveolar lavage fluid.