Table 10.

Summary of the main histological evidences and differential expression of genes triggering and related to ECM remodeling in Pectoralis major muscles exhibiting myopathic conditions.

Main findings	References
Histological evidences
↑ deposition of fibrillar collagen (from week 4 onwards)	Kuttappan et al., 2013; Sihvo et al., 2014, 2017; Soglia et al., 2016b; Papah et al., 2017
Gene expression
↑ genes belonging to the collagen family	Mutryn et al., 2015; Papah et al., 2018; Bordini et al., 2021
↑ genes involved in ECM remodeling and fibroblasts proliferation and function	Mutryn et al., 2015; Papah et al., 2018; Brothers et al., 2019; Pampouille et al., 2019; Bordini et al., 2021
↑ PDGFRA supporting the activation of FAPs	Papah et al., 2018; Pampouille et al., 2019
↑ Wnt signaling	Philips et al., 2020; Bordini et al., 2021

Abbreviations: ECM, extracellular matrix; FAPs, fibro-adipogenic precursors.