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. 2021 May 18;12:2928. doi: 10.1038/s41467-021-23250-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Time-dependent in vivo fluorescence imaging to explore the whole-body biodistribution kinetics of siRNA/Ap-CS and its tumor localization. A549 tumor-bearing BALB/c nude mice were used, and the samples, including PBS, siRNA, siRNA/ADC-AuNP, and siRNA/Ap-CS, were administrated to the mice via tail vein injection. b The fluorescence intensity of tumor sites in the white circles in panel a. The error bar represents the standard deviation (SD). The measured data are expressed as the means ± SD (n = 3). c Fluorescence images of the organs harvested at 90-min post injection of siRNA/Ap-CS, accompanied by the quantitative assessment of fluorescence intensity from liver and tumor (d) where the fluorescence ratio of tumor-to-liver (T/L) is also presented. The PS-ADC (Plk1 sense partly complementary to ADC) and PA-Cy5 (Cy5-labeled Plk1 antisense) were used for the preparation of siPlk1 duplex. The error bar represents the standard deviation (SD). The measured data are expressed as the means ± SD (n = 3).