Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 May 18;11:10495. doi: 10.1038/s41598-021-89860-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

STAT3 co-ordinates downstream IL-4 signalling outcomes in T cells. Studies have shown, for the first time, that STAT3 signalling capability is critical to regulating T cell supply of IL-4R⍺ and, by extension, responsiveness to the IL-4 environment. Subsequently, inhibition of STAT3 resulted in ablated STAT6 engagement. We suspect this affects IL-4 signalling outcomes, including the production of TGF-β1, GATA3 and IFN-γR1. Collectively, this molecular mechanism may have profound implications for T cell fate and function during infection/vaccination. Created using BioRender.