Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
HIF signaling network in normoxic and hypoxic conditions. In hypoxia condition, HIF-1α is able to increase angiogenesis process, proliferation, therapy resistance mechanisms and stem cell maintenance. Under normoxic condition, VHL is the recognition component of an E3 ubiquitin-protein-ligase, target for the proteasomal degradation of HIF-1α. As a result, HIF-1α is modified and it is recognized by a proteasome and rapidly degraded.
