Table 1.
In vivo studies of BMPs with phenotypes related to adipose tissue
| Gene/protein | Way of manipulating | Phenotype (WAT) | Phenotype (BAT) | Reference |
|---|---|---|---|---|
| BMP4 | Ap2 promoter—transgenic | Browning of WAT WAT mass↑ Vasculature↑ |
Whitening of BAT | (21) |
| BMP4 | Adenovirus injection at BAT local site | Not mentioned | Whitening of BAT | (202) |
| BMP4 | Ap2-cre-drived knockout | WAT mass↑ Lipid accumulation↑ |
BAT mass↑ Lipid accumulation↑ |
(21) |
| BMP7 | Whole-body null | Compensatory browning of WAT | BAT mass↓ | (185) |
| BMP7 | Injection of peptide via subcutaneous osmotic minipumps | Browning of WAT WAT mass↓ |
BAT mass↓ | (196) |
| BMP7 | Adenovirus injection via tail vein | No change of WAT mass | BAT mass↑ | (185) |
| BMP8B | Whole-body knockout (challenged with HFD) | Not mentioned | BAT mass↑ Lipid droplet↑ |
(197) |
| BMP3B | Ap2 promoter—transgenic | WAT mass↓ | No change of BAT mass | (224) |
| BMP14 | Ap2 promoter—transgenic | Browning of WAT | Adipogenesis↑ | (225) |
| BMPR1A | Myf5-cre/ap2-cre-drived knockout | Browning of WAT Innervation of WAT↑ |
BAT mass↓ | (195) |
| BMPR2 | Ap2-cre-drived knockout | Loss of WAT at periweaning | No change of BAT mass | (209) |
BAT, brown adipose tissue; BMP, bone morphogenetic protein; WAT, white adipose tissue.