Table 3.
Physiological parameters after 4 weeks of high-dose Ang II treatment in murine model
| Physiological parameters | Ctrl | Ctrl-Cana | Ang II | Ang II-Cana |
|---|---|---|---|---|
| BW (g) | 33.7 ± 1.2 | 31.1 ± 0.59 | 28.1 ± 1.3a | 26.9 ± 1.0b |
| SBP (mmHg) | 110 ± 4 | 111 ± 3 | 165 ± 7b,c | 158 ± 3b,c |
| Heart rate (bpm) | 708 ± 10 | 702 ± 10 | 615 ± 21b,c | 673 ± 9d |
| Food intake (mg/24h) | 214 ± 44 | 438 ± 68 | 191 ± 60 | 1023 ± 250a,e,f |
| Water intake (ml/24h) | 2.3 ± 0.2 | 3.1 ± 0.3 | 4.6 ± 0.4a | 6.7 ± 0.7b,c,d |
| Urine volume (ul/24h) | 864 ± 114 | 1119 ± 72 | 1546 ± 402 | 3093 ± 677a,d,g |
| Urine glucose (mg/24h) | 0.32 ± 0.11 | 34.3 ± 9.7 | 1.09 ± 0.5 | 98.2 ± 29.5b,f,h |
| KW/TL (mg/mm) | 12.8 ± 0.4 | 13.4 ± 0.2 | 10.7 ± 0.6a,c | 12.0 ± 0.4 |
| KW/BW (mg/g) | 8.6 ± 0.4 | 10.1 ± 0.3 | 9.6 ± 0.3 | 10.5 ± 0.5i |
| HW/TL (mg/mm) | 5.1 ± 0.2 | 4.9 ± 0.1 | 6.4 ± 0.2a,c | 6.5 ± 0.3a,c |
| HW/BW (mg/g) | 3.7 ± 0.1 | 3.8 ± 0.1 | 5.4 ± 0.3b,c | 5.8 ± 0.4b,c |
| GFR | 280.9 ± 19.5 | 226.0 ± 20.1 | 115.7 ± 22.3b,i | 145.9 ± 35.2a |
| Hematocrit (%) | 50.5 ± 0.8 | 50.1 ± 0.9 | 57.6 ± 1.4a | 60.7 ± 2.0b,c |
| BUN (mmol/L) † | 13.3 ± 0.9 | 13.2 ± 0.7 | 22.1 ± 2.3a | 24.0 ± 1.2b,c |
| Serum Creatinine (umol/L) † | 16.7 ± 2.1 | 15.3 ± 1.6 | 34.0 ± 8.2e,i | 26.0 ± 3.4 |
| Serum Na+ (mEq/L) † | 148.3 ± 1.1 | 154.7 ± 1.5h | 149.2 ± 2.1 | 156.0 ± 1.2a,d |
| Serum K+ (mEq/L) † | 5.0 ± 0.1 | 5.0 ± 0.2 | 5.3 ± 0.3 | 5.1 ± 0.2 |
| Urine Na+ (mEq/day) † | 61.6 ± 10.8 | 93.4 ± 14.9 | 65.6 ± 12.8 | 72.1 ± 17.5 |
| Urine K+ (mEq/day) † | 81.7 ± 12.0 | 130.8 ± 22.9 | 159.8 ± 25.1 | 185.2 ± 36.6i |
| FeNa (%)† | 0.11 ± 0.01 | 0.19 ± 0.04 | 0.24 ± 0.09 | 0.26 ± 0.07 |
| EFWC (ul/min) † | −0.09 ± 0.04 | −0.28 ± 0.13 | −0.07 ± 0.12 | 0.63 ± 0.33e |
BW, body weight; SBP, systolic blood pressure; KW, kidney weight; TL, tibia length; HW, heart weight; FeNa, Fractional sodium excretion; EFWC, electrolyte-free water clearance. N=8/group except for parameters with
†
which are N=6/group.
a.
p<0.01 vs Ctrl
b
. p<0.001 vs Ctrl
c.
p<0.001 vs Ctrl-Cana
d.
p<0.05 vs Ang II
e.
p<0.05 vs Ctrl-Cana
f.
p<0.001 vs Ang II
g.
p<0.01 vs Ctrl-Cana
h.
p<0.05 vs Ctrl-Cana
i.
p<0.05 vs Ctrl.