Table 1.
Patient demographics
| ICT-107 | Control DC | Total | |
|---|---|---|---|
| # Subjects randomized | 81 | 43 | 124 |
| # Subjects completed treatment | 75 | 42 | 117 |
| Subjects by age group | |||
| Median (years) | 59.0 | 59.8 | 59.2 |
| Mean (years) | 57.4 | 57.5 | 57.4 |
| <50 years | 20 (24.7%) | 12 (27.9%) | 32 (25.8%) |
| ≥50 years | 61 (75.3%) | 31 (72.1%) | 92 (74.2%) |
| ≥50 and <65 years | 39 (48.2%) | 17 (39.55) | 56 (45.2%) |
| ≥65 years | 22 (27.2%) | 14 (32.6%) | 36 (29.0%) |
| Gender | |||
| Males | 44 (54.3%) | 31 (72.1%) | 75 (60.5%) |
| Females | 37 (45.7%) | 12 (27.9%) | 49 (39.5%) |
| HLA haplotype | |||
| HLA-A1 (HLA-A2−) | 33 (40.7%) | 14 (32.6%) | 47 (37.9%) |
| HLA-A2 (HLA-A1−) | 42 (51.9%) | 22 (51.2%) | 64 (51.6%) |
| HLA-A1, A2 | 6 (7.4%) | 7 (16.3%) | 13 (10.5%) |
| All HLA A2+ | 48 (59.3%) | 29 (67.4%) | 77 (62.1%) |
| MGMT statusa | |||
| Methylated | 28 (34.6%) | 18 (41.9%) | 46 (37.1%) |
| Unmethylated | 47 (58.0%) | 24 (55.8%) | 71 (57.3%) |
| KPS categoryb | |||
| 100 | 24 (29.6%) | 8 (18.6%) | 32 (25.8%) |
| 90 | 36 (44.4%) | 18 (41.9%) | 54 (43.5%) |
| <90 | 20 (24.7%) | 17 (39.5%) | 37 (29.8%) |
| Resection status | |||
| Complete resection | 58 (71.6%) | 32 (74.4%) | 90 (72.6%) |
| Subtotal resection | 23 (28.4%) | 11 (25.6%) | 34 (27.4%) |
a
Six patients in the ICT-10 group and 1 patient in the control group did not have MGMT methylation data.
b
KPS data missing from 1 patient in ICT-107 group.