Fig. 4. Selonsertib did not affect the localization of ABCB1 or ABCG2 transporters in ABCB1 or ABCG2 overexpressing cell lines.
Sub-cellular localization of ABCB1 expression in KB-C2 (A) and ABCG2 expression in NCI-H460/MX20 (B) cells incubated with 10 μM of selonsertib for 0, 24, 48, and 72 h. ABCB1, green and ABCG2, blue. DAPI counterstains the nuclei. KB-3–1 and NCI-H460 represented the control group; Scale bar: 200 μm. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)