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. Author manuscript; available in PMC: 2021 May 19.
Published in final edited form as: Cancer Lett. 2018 Oct 10;440-441:82–93. doi: 10.1016/j.canlet.2018.10.007

Fig. 5. Selonsertib increased the intracellular [3H]-drug accumulation in cancer cells overexpressing ABCB1 and ABCG2.

Fig. 5.

(A) The effect of selonsertib on the accumulation of [3H]-paclitaxel in KB-3–1 and KB-C2 cell lines. (B) The effect of selonsertib on the accumulation of [3H]-paclitaxel in SW620 and SW620/Ad300 cell lines. (C) The effect of selonsertib on the accumulation of [3H]-mitoxantrone in NCI-H460 and NCI-H460/MX20 cell lines. (D) The effect of selonsertib on the accumulation of [3H]-mitoxantrone in S1 and S1-M1–80 cell lines. Verapamil (10 μM) and Ko 143 (10 μM) were used as positive controls for ABCB1 and ABCG2 overexpressing cells respectively. Data are mean, representative of three independent experiments. *p < 0.05, compared with control group. Selo, selonsertib; Vera, verapamil and Ko, Ko 143.