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. Author manuscript; available in PMC: 2021 May 19.
Published in final edited form as: Cancer Lett. 2019 Jan 11;445:34–44. doi: 10.1016/j.canlet.2019.01.001

Fig. 7. A graphic illustration of midostaurin modulating the drug efflux function of ABCB1 in cancer cells.

Fig. 7.

(A) In the absence of midostaurin, anticancer drugs (grey circles) are effluxed out of ABCB1-overepressing cancer cells by ABCB1 (green), preventing the accumulation of therapeutic drugs in cancer cells, which leads to the MDR phenotype. (B) In the presence of midostaurin, the drug effux function of ABCB1 is blocked by midostaurin and the chemosensitivity of ABCB1-overexpressing cancer cells is hence restored. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)