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. Author manuscript; available in PMC: 2021 May 19.
Published in final edited form as: Cancer Lett. 2019 Jan 11;445:34–44. doi: 10.1016/j.canlet.2019.01.001

Table 3.

Sensitivity of ABCBl-expressing cells and their respective drug-sensitive parental cells to midostaurin.

Cell line Transporter expressed IC50 [μM]a R.Rb
KB-3–1 – 0.64 ± 0.11 1.0
KB-V-1 ABCB1 0.74 ± 0.23 1.2
OVCAR-8 – 2.03 ± 0.36 1.0
NCI-ADR-RES ABCB1 3.16 ± 0.83 1.6
NIH3T3 – 0.62 ± 0.11 1.0
NIH3T3-G185 ABCB1 0.84 ± 0.17 1.4

Abbreviation: RR, relative-resistance.

a

IC50 values are mean ± SD calculated from dose-response curves obtained from at least three independent experiments using cytotoxicity assay as described in Materials and methods.

b

RR values were calculated by dividing IC50 values of ABCBl-overexpressing multidrug-resistant cells by IC50 values of respective drug-sensitive parental cells treated with midostaurin.