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. Author manuscript; available in PMC: 2021 Nov 9.
Published in final edited form as: Curr Diab Rep. 2020 Nov 9;20(12):69. doi: 10.1007/s11892-020-01355-3

Table 2.

Studies investigating PRS to predict GDM/T2D, or glycemic traits during pregnancy

First author Year Ancestry Outcome Sample size (case/control) Number of variants Variant selection for PS Method of PS Risk of outcome by PS Other findings

Moen GH 2018 European Fasting Glucose 529 33 FG variants Weighted PS NA GRS explained 4.95% of variance of FG GW 14–16
Powe CE 2018 European Fasting Glucose (Gen3G) 551 38 FG variants Weighted PS 0.39 (0.27–0.51) per unit increase GRS explained 7% of variance of FG
Powe CE 2018 European Fasting Glucose (HAPO) 1380 38 FG variants Weighted PS 0.42 (0.06–0.18) per unit increase GRS explained 7% of variance of FG
Lauenborg J 2008 European GDM 2127 (244/1883) 11 T2D variants Weighted PS 1.18 (1.10–1.27) per unit increase AUC ROC clinical 0.62; AUC ROC clinical + PS 0.68
Sullivan SD 2014 Multi-ethnic GDM 1383 (281/1102) 34 T2D variants Weighted PS 1.05 (1.00–1.08) per unit increase
Comrier H 2015 European GDM 296 (214/82) 36 T2D variants Explained-variance PS NA Significantly higher PS in cases vs controls (1.21 ± 0.18 vs 1.17 ±0.15, P< 0.0001)
Kawai VK 2017 European GDM 1996 (458/1538) 34 T2D or FG variants Weighted PS 1.11 (1.08–1.14) per unit increase AUC ROC clinical 0.67; AUC ROC clinical + PS 0.70
Ding M 2018 European GDM 8722 (2636/6086) 11 T2D variants Weighted PS 1.04 (1.03–1.05) per unit increase
Powe CE 2018 European GDM (Gen3G) 551 (43/508) 85 T2D variants Weighted PS 1.06 (1.01–1.10) per unit increase
Powe CE 2018 European GDM (HAPO) 1380 (207/1173) 85 T2D variants Weighted PS 1.03 (1.01–1.06) per unit increase
Ekelund M 2012 Multi-ethnic T2D 637 (134/503) 13 T2D variants Weighted PS 1.11 (1.05–1.18) per unit increase
KwakSH 2013 East Asian T2D 395 (116/279) 48 T2D variants Weighted PS 1.66 (1.30–2.13) per unit increase AUC ROC clinical 0.74; AUC ROC clinical + PS 0.78
Comrier H 2015 European T2D/Prediabetes 214 (135/79) 36 T2D variants Explained-variance NA AUC ROC clinical 0.63; AUC ROC clinical + PS 0.67
LiM 2020 European T2D 2434 (601/1833) 59 T2D or FG variants Unweighted PS 1.07(1.01–1.14) per 5 risk alleles

AUC, area under the curve; FG, fasting glucose; GW, gestational week; NA, not available; PS, polygenic score; ROC, receiver operating characteristics; T2D, type 2 diabetes