A) Quality of life measurements in 95 relapsing (RRMS) and 27 progressive patients were assessed using the NeuroQOL questionnaire across three domains: physical, mental, and social. Departure from the population norm (T score = 50) in RRMS and progressive patients. B) Microbiota correlations with quality of life, Spearman correlation adjusted for age. * p<0.05, **<0.01, ***< 0.001.