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Antiviral activity (EC50), toxicity (TC50), and selectivity index (SI; TC50/EC50) data for heteroatom-substituted mercaptobenzamide prodrug analogs.
 | |||||||
|---|---|---|---|---|---|---|---|
| Compound | X | Y | Z | n | EC50 [μM] | TC50 [μM] | SI |
| 43 | S | O | NH2 | 1 | >100 | 82.1 ± 18.1 | – |
| 44 | S | NH | OCH3 | 1 | >100 | 27.3 ± 2.8 | – |
| 45 | Se | NH | NH2 | 1 | >100 | 6.8 ± 0.7 | – |
| 46 | Se | NH | NH2 | 2 | 8.6 ± 1.6 | 10.5 ± 9.7 | 1.22 |
