. Author manuscript; available in PMC: 2021 May 19.

Published in final edited form as: Eur J Med Chem. 2019 Jun 9;178:818–837. doi: 10.1016/j.ejmech.2019.06.020

Table 4.

Antiviral activity (EC₅₀), toxicity (TC₅₀), and selectivity index (SI; TC₅₀/EC₅₀) data for “methyl-scanned”, homologated, and dehomologated mercaptobenzamide prodrugs.



Compound	R	EC₅₀ [μM]	TC₅₀ [μM]	SI

47		1.4 ± 1.3	>100	71.4
48		4.7 ± 2.6	38.3 ± 0.6	8.15
49		>100	55.3 ± 8.8	–
50		>100	62.5 ± 10.0	–
51		>100	57.3 ± 8.6	–
52		>100	>100	–
53		>100	5.7 ± 0.8	–
54		>100	12.4 ± 7.6	–
55		>100	>100	–