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. Author manuscript; available in PMC: 2021 May 19.
Published in final edited form as: Eur J Med Chem. 2019 Jun 9;178:818–837. doi: 10.1016/j.ejmech.2019.06.020

Table 5.

Antiviral activity (EC50), toxicity (TC50), and selectivity index (SI; TC50/EC50) data for terminus-modified mercaptobenzamide prodrugs.

graphic file with name nihms-1695712-t0038.jpg
Compound R EC50 [μM] TC50 [μM] SI
56 graphic file with name nihms-1695712-t0039.jpg 5.0 ± 3.1 92.0 ± 11.4 18.4
57 graphic file with name nihms-1695712-t0040.jpg 4.7 ± 0.2 95.4 ± 6.6 20.3
58 graphic file with name nihms-1695712-t0041.jpg 4.8 ± 0.8 29.3 ± 10.4 6.10
59 graphic file with name nihms-1695712-t0042.jpg 10.3 ± 7.0 24.8 ± 19.5 2.41
60 graphic file with name nihms-1695712-t0043.jpg 9.1 ± 6.7 46.8 ± 11.2 5.14
61 graphic file with name nihms-1695712-t0044.jpg 6.6 ± 3.4 76.9 ± 10.8 11.6
62 graphic file with name nihms-1695712-t0045.jpg 4.9 ± 1.1 >100 20.4
63 graphic file with name nihms-1695712-t0046.jpg 27.5 ± 25.7 >100 3.64