Table 2.
Gain and loss of developmental milestones in CD patients: study cohort versus literature
| Milestones of psychomotor development | Patients who gained function, n (N) percentage | Patients who lost function, n (N) percentage | Age of gain, median (range), mo | Age of loss, median (range), mo | Normal age of gain (DDST II), ranges, mo | Patients who gained function, Traeger et al., n (N) percentage | Patients who lost funktion, Traeger et al., n (N) percentage | Age of gain, Traeger et al., median (range), mo | Age of loss, Traeger et al., median (range), mo |
|---|---|---|---|---|---|---|---|---|---|
| Hearing/Vision | |||||||||
| Visual tracking |
12/23 52% |
7/23 30% |
4 (0–15) | 14 (1–132) | 0–4 |
33/59 56% |
10/59 17% |
4 (1–18) | 12 (4–44) |
| Hearing |
23/23 100% |
0/23 0% |
0 (0–0) | 0 | |||||
| Gross Motor Skills | |||||||||
| Head control |
6/23 26% |
2/22 9% |
6 (2–10) | 6 (6–6) | 1.5–4 |
11/59 19% |
8/59 14% |
6 (1–24) | 11.5 (2–180) |
| Rolling over |
9/23 39% |
7/22 32% |
6 (2–12) | 11 (4–120) | 4.25–5.5 |
17/59 29% |
7/59 12% |
6 (2–24) | 11.5 (6–72) |
| Sitting with support |
6/23 26% |
2/23 9% |
5.5 (4–8) | 15 (6–24) | |||||
| Sitting without support |
2/23 9% |
1/23 4% |
11.5 (11–12) | 120 | 6.75–8 |
1/59 2% |
1/59 2% |
10 | 60 |
| Crawling | 0/22 | – | – | – |
1/59 2% |
1/59 2% |
10 | 72 | |
| Standing with support |
1/23 4% |
1/22 5% |
13 | 132 | 6.75–10.5 | ||||
| Standing without support | 0/23 | – | – | – | 11.25–16 | ||||
| Walking with support |
3/23 13% |
2/23 9% |
18 (15–19) | 84 (36–132) | |||||
| Walking | 0/23 | – | – | – | 12.25–16 | ||||
| Fine Motor Skills | |||||||||
| Reaching for an object |
7/22 30% |
2/22 9% |
7 (4–10) | 69 (6–132) | 3.5–6 | ||||
| Voluntary hand function |
7/23 30% |
1/22 5% |
7 (1–18) | 6 | |||||
| Transfer an item |
5/23 22% |
4/23 17% |
9 (4–18) | 31 (6–132) | 5–8.75 | ||||
| Scribbling/drawing |
3/23 13% |
2/23 9% |
9 | 78 (24–132) | 12.25–21 | ||||
| Language/Other | |||||||||
| Imitating noises |
3/22 13% |
2/22 9% |
11 (10–12) | 96 (60–132) | 6.5–12.75 | ||||
| Squealing /babbling |
5/16 31% |
2/15 13% |
8 (4–55) | 156 (132–180) | 1.5–3.75 |
10/59 17% |
0/59 | 5 (1–18) | – |
| Understand language |
11/23 48% |
1/22 5% |
11 (7–24) | 7 | – | ||||
| Reactive smiling |
7/11 64% |
2/11 18% |
5 (1–14) | 205.5 (132–281) | 0–1.5 |
43/60 72% |
4/60 7% |
3 (0–36) | 13.5 (4–150) |
| Communicate |
8/22 36% |
1/22 5% |
11 (4–24) | 180* | – | ||||
| Single words |
3/23 13% |
2/23 9% |
24 (12–24) | 93.5 (48–139) | 10–14.5 |
2/59 3% |
1/59 2% |
23.5 (11–36) | 180 |
| Single sentences | 0/23 | – | – | ||||||
| Count to five |
1/23 4% |
1/23 4% |
60* | 132* | |||||
| Independent eating |
2/23 9% |
0/23 | 11 | – | |||||
| Toilet trained | 0/23 | – | – | – |