Table 1.

Main characteristics regarding the three cases of chronic PJI in which, after multiple surgical interventions, the latter revision was performed using the FTBL technique.

Case number	Age (years)	Sex	Femoral bone loss${}^{*}$	Causative microorganism	Tetracycline dosage and administrationperiod	Surgical intervention	Histological findings	Follow-up (12 months)
Case 1	67	Female	IIIA	Meticillin-resistant Staphylococcus aureus	Minocycline 100 mg every 12 h orallyfor 4 weeks	Spacer removal andreimplantation	Late fibrosis of marrow with chronic inflammatory infiltrate and plasma cell predominance along with fragments of necrotic bone, consistent with osteomyelitis; $<$ 5 neutrophils per high-power field.	Absence of relapse
Case 2	40	Male	II	Meticillin-resistant Staphylococcus aureus	Minocycline 100 mg every 12 h orallyfor 10 d	First stage of a two-stage septic revision	Late fibrosis of marrow with chronic inflammatory infiltrate along with fragments of necrotic bone and bone marrow edema, consistent with osteomyelitis; $>$ 5 neutrophils per high-power field.	Absence of relapse,waiting for the secondstage of the revision
Case 3	68	Female	I	Escherichia coli	Minocycline 100 mg every 12 h orally for 7 d	Reimplantation	Bone tissue with reactive vascular proliferation and chronic inflammatory infiltrate along with fragments of necrotic bone and bone marrow edema, consistent with osteomyelitis; $<$ 5 neutrophils per high-power field.	Absence of relapse

${}^{*}$ Femoral bone loss according to the Paprosky classification (Weeden and Paprosky, 2002).